A strange salesman is ran out of a local village by its inhabitants. He throws the contents of his briefcase over a cliff edge and into the lake below. Soon after, strange things begin to happen. Young men start to throw themselves off the same cliff, offering themselves to some strange entity beneath the water.

On a harsh snowy mountain, three hikers discover a naked body sticking out of the ice. Surprising to them, the girl they have found is still alive. She introduces herself as Tomie, and things then begin to go from bad to worse.

Following on from Morita Hospital, there seems to be some strange things happening in the Hospital Basement. A mysterious growth is beginning to take a familiar form.

A young girl awaiting a kidney transplant meets the mysterious Tomie through a friend of hers. But after a warning by Tomie to stop seeing that friend, it seems she has much more to give the patient than just threats.

Tomie kicked off what was to become one of the most engrossing and enjoyable horror manga series I have ever read. Not only that but this, its first chapter, kicked off the career of perhaps the most well known and celebrated mangaka, Junji Ito.